
Commercial Sale · Retail
3425 22ND AVENUE S, ST PETERSBURG, FL, 33711
Active383 days on marketListed Sep 25, 2025MLS #TB8431429
About this property
The property at a glance
TWO-BUILDING COMMERCIAL PROPERTY | SOUTH ST. PETERSBURG CRA | 22ND AVENUE SOUTH High-Visibility Owner-User or Investment Opportunity in South St. Petersburg Positioned along 22nd Avenue South with additional visibility from 34th Street South, this versatile commercial property offers an excellent opportunity for an owner-user, investor, or entrepreneur seeking a highly visible location in South St. Petersburg. The property features two separate buildings, providing flexibility for a variety of business uses, additional workspace, or a combination of customer-facing and back-office operations. The main building was previously operated as a hair salon and retains much of the interior configuration associated with its prior use, including plumbing, electrical wiring, HVAC, and salon-related improvements. This existing build-out may provide an opportunity for a future salon, beauty, wellness, or service-oriented operator to reduce initial renovation and build-out costs. Salon equipment is negotiable, including styling chairs, stations, dryers and other related equipment. A separate secondary building/outbuilding includes its own restroom, creating valuable additional space that could be used as a private office, workshop, studio, storage area, employee space, or other ancillary commercial use, subject to applicable zoning and permitting. The property also includes onsite parking, providing convenient access for customers, employees, and business operations. SOUTH ST. PETERSBURG CRA LOCATION The property is located within the South St. Petersburg Community Redevelopment Area (CRA) in the Greater Childs Park area. The CRA is an established area targeted for continued economic development, neighborhood investment, commercial revitalization, and private-sector reinvestment. This CRA designation adds an additional investment consideration for buyers looking to establish or improve a commercial property in an area benefiting from ongoing redevelopment efforts. MULTIPLE POTENTIAL USES The property’s existing commercial infrastructure and two-building configuration provide flexibility for a variety of potential businesses, subject to zoning and permitting, including: • Hair salon or barber shop • Wellness or personal training studio • Boutique or specialty retail • Creative or photography studio • Professional office • Training or educational center • Workshop or service-oriented business • Veterinary or pet-related use • Storage or ancillary commercial use • Other neighborhood-serving commercial businesses The property was also previously used as a veterinary office, demonstrating the versatility of the space for different commercial applications. HIGH-VISIBILITY LOCATION Located on 22nd Avenue South, the property benefits from frontage and exposure along an established St. Petersburg commercial corridor, with additional visibility from 34th Street South. Its location provides convenient access to surrounding residential neighborhoods and major St. Petersburg thoroughfares. Buyer to independently verify zoning, permitted uses, building dimensions, square footage, parking, utilities, building systems, CRA eligibility, development potential and all other property information with the City of St. Petersburg and applicable governmental authorities.
2,372
Building sq ft
$306
Price / sq ft
0.27
Lot acres
1950
Year built
2
Buildings
1120
Zoning
Retail
Property type
The numbers
Investment snapshot
Income and lease details aren’t published in the MLS for this listing. Ask for the offering memorandum and rent roll to run cap rate, NOI and cash-on-cash.
Estimated payment (illustrative)
Estimated payment
$3,651/mo
Illustrative only. Commercial loans are underwritten on the property’s income (DSCR, cap rate) — typically 25–35% down with lender-set terms. Ask a commercial lender for real numbers. Taxes reflect the most recent bill on record; insurance is a typical-Florida estimate. Your lender’s numbers will differ. CENTURY 21 Edge partners with Florida’s best lenders.
Financing
Commercial financing works differently from a home loan — expect roughly 25–35% down with terms driven by the property’s income and your lender’s underwriting (DSCR, cap rate), not FHA or VA programs. Ask Donna to connect you with a commercial lender for real numbers.
Where it sits
Location & trade area
What’s nearby
Business data © OpenStreetMap contributors
The area
Who's around this property
6,497
Population
$42,874
Median income
38
Median age
3
Avg household
$170,059
Median home value
$1,077/mo
Median rent
782
Households w/ kids
Consumer profile
Driven to succeed in the business world, this population seeks to progress in their career through networking happy hours, summits, and connecting with other professionals online.
Who says the body isn't a canvas? This population loves talking about tattoos, body art and piercings.
Passionate about all things hair, this population is talking about hair tutorials or the hottest celebrity blowout.
A population characterized by healthy eating. Often pre-planning for meals for the purpose of fitness and convenience. Likely to participate in meal prep trends.
Expressing a desire to give back and do good for the community, this behavior emphasizes charity. Common activities include volunteering, fundraisers, and donations.
This population seeks to advocate for a more just world. Common activities include protests, rallies, and spreading awareness to the public about social justice issues.
Recent sales
What actually sold near 3425 22ND AVENUE S
The most comparable commercial properties that changed hands nearby. No two are identical — ask us for a full comparative analysis.

$41,000
2452 CENTRAL AVENUE
1,640 sqft · $25/sqft · Sold Jan 21, 2025

$13,104
5211 GULFPORT BOULEVARD S
1,700 sqft · $8/sqft · Sold Mar 12, 2026

$217,375
922 DR MARTIN LUTHER KING JR STREET S
1,784 sqft · $122/sqft · Sold Oct 3, 2025
Your team
The pros in your corner
Your agent
Donna Layton
Real Estate Agent · CENTURY 21 Edge
Tours, offers, and every question about 3425 22ND AVENUE S — start here.

Financing contact
Andrew Acosta
Acosta Home Loans with PRMG · NMLS #1468866
Ask about commercial financing options for 3425 22ND AVENUE S.
See it in person
Schedule a tour
Live availability from Donna's calendar — pick a time and it's booked.
Keep looking
Similar properties nearby
Listing courtesy of CENTURY 21 BEGGINS · Kristy Murphy. MLS #TB8431429.
IDX information is provided exclusively for consumers’ personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Data is deemed reliable but is not guaranteed accurate by Stellar MLS.
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